by ibuprofen overdose . Atrial fibrillation induced
نویسنده
چکیده
Sir, I read with interest the case report of Shalev et al.} on falciparum malaria-induced hypoglycaemia, and I wish to suggest another possible and important mechanism in the pathogenesis of hypoglycaemia associated with falciparum malaria infection. Several recent studies have demonstrated elevated serum levels of tumour necrosis factor-a (TNF) in patients with falciparum malaria,2-6 where this cytokine was also shown to play an important role in the pathogenesis of this serious and potentially fatal infection.2-5'7,8 Furthermore, organ impairment in human falciparum malaria was found to be correlated with the amount of circulatory levels of TNF.4'5 On the other hand, overproduction of TNF may induce profound hypoglycaemia.912 Thus, also elevated circulatory levels ofTNF may be responsible for the hypoglycaemia associated with falciparum malaria. The mechanisms by which TNF induces hypoglycaemia are not fully understood. In this regard, it is reasonable to suggest that the beneficial therapeutic effects of the antimalarial agents in malarial infection may be partially mediated through blockade of TNF release, as recent studies have demonstrated that chloroquine inhibits TNF production."3-'5
منابع مشابه
Ibuprofen-induced Kounis syndrome with diffuse ST segment depression and atrial fibrillation
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تاریخ انتشار 2008